Products related to Biomarkers:
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Biomarkers in Inflammatory Bowel Diseases
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner.The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
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Handbook of Biomarkers and Precision Medicine
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches.By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of HealthHandbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine.A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments.The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine.They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia.Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK.Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK.Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
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Leong's Manual of Diagnostic Biomarkers for Immunohistology
With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice.This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format.Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis.Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.
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Salivary Biomarkers for Oral and Systemic Diseases
Salivary Biomarkers for Oral and Systemic Diseases contains contributions from a number of experts and highly regarded scientists and clinicians.This book offers unique insights into the science of biomarkers in oral diseases and how to use biomarkers to help in the diagnosis of both oral and systemic diseases.The book focuses on all oral fluids, such as GCF, peri-implant fluid, and whole mouth saliva, and outlines the practical importance of the use of other biological samples from the oral cavity.This is a must-have reference for all those interested in salivary biomarkers across the bioscience and biomedical fields.
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Which distro do you use, Linux users?
As an AI, I do not have personal preferences or the ability to use operating systems. However, Linux users often choose their distribution based on their specific needs and preferences. Some popular distributions include Ubuntu for its user-friendly interface, Fedora for its focus on the latest technologies, and Debian for its stability and reliability. Ultimately, the choice of distribution depends on the user's requirements and level of expertise.
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How can one downgrade the Linux kernel?
To downgrade the Linux kernel, you can follow these steps: 1. First, identify the version of the kernel you want to downgrade to and make sure it is available in your distribution's package repository. 2. Next, use the package manager of your Linux distribution to remove the current kernel version. For example, in Ubuntu, you can use the command `sudo apt-get remove linux-image-<version>`. 3. Then, install the desired kernel version using the package manager. For example, in Ubuntu, you can use the command `sudo apt-get install linux-image-<desired_version>`. 4. Finally, reboot your system to load the downgraded kernel. Keep in mind that downgrading the kernel may have implications for system stability and compatibility with hardware and software, so it's important to carefully consider the reasons for downgrading and to backup important data before proceeding.
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What makes the Linux kernel so special?
The Linux kernel is special for several reasons. Firstly, it is open-source, meaning that its source code is freely available for anyone to use, modify, and distribute. This has led to a large and active community of developers constantly improving and updating the kernel. Additionally, the Linux kernel is highly customizable and can be tailored to specific needs, making it suitable for a wide range of devices and systems. Finally, the Linux kernel is known for its stability, security, and performance, making it a popular choice for servers, embedded systems, and other critical applications.
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Why can't the Linux kernel be loaded?
The Linux kernel cannot be loaded because it is a fundamental part of the operating system that needs to be present in memory before any other software can run. The kernel is responsible for managing the system's resources, such as memory, CPU, and devices, and it provides essential services for other software to function. Without the kernel, the operating system cannot start and the computer cannot run any programs. Therefore, the kernel needs to be loaded into memory during the boot process in order for the operating system to become operational.
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Exosomes in Cardiovascular Diseases : Biomarkers, Pathological and Therapeutic Effects
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects.It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well.Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized.Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy.Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted.Finally, future prospects of exosomes in cardiovascular research would be provided.This is an essential reference for researchers working in cell biology and regeneration, as well as clinicianssuch as cardiologist.
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Learning eBPF : Programming the Linux Kernel for Enhanced Observability, Networking, and Security
What is eBPF? With this revolutionary technology, you can write custom code that dynamically changes the way the kernel behaves.It's an extraordinary platform for building a whole new generation of security, observability, and networking tools. This practical book is ideal for developers, system administrators, operators, and students who are curious about eBPF and want to know how it works.Author Liz Rice, chief open source officer with cloud native networking and security specialists Isovalent, also provides a foundation for those who want to explore writing eBPF programs themselves. With this book, you will:Learn why eBPF has become so important in the past couple of yearsWrite basic eBPF code, and manipulate eBPF programs and attach them to eventsExplore how eBPF components interact with Linux to dynamically change the operating system's behaviorLearn how tools based on eBPF can instrument applications without changes to the apps or their configurationDiscover how this technology enables new tools for observability, security, and networking
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Drug Development for Gene Therapy : Translational Biomarkers, Bioanalysis, and Companion Diagnostics
Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use.The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives.The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries.To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters.Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues.Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsidsDetection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy productsNonclinical and clinical study considerations and methods for biodistribution and sheddingQuantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapyDetection and quantification of rAAV integration and off-target editingCurrent regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.
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Genomic and Epigenomic Biomarkers of Toxicology and Disease : Clinical and Therapeutic Actions
Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas.With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazardComprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicinePractical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesotheliomaIn-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.
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How can I activate a newer Linux kernel?
To activate a newer Linux kernel, you can follow these steps: 1. Download the desired kernel version from the official Linux kernel website. 2. Compile the kernel source code on your system using the appropriate tools and configurations. 3. Install the newly compiled kernel on your system and update the bootloader configuration to boot from the new kernel. 4. Reboot your system to activate the newer Linux kernel.
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How can one use Linux Ubuntu for programming server applications and similar tasks?
To use Linux Ubuntu for programming server applications and similar tasks, one can start by installing the necessary programming languages and tools such as Python, Ruby, Node.js, or Java. Ubuntu's package manager, apt, can be used to easily install these tools. Next, one can set up a development environment by installing a text editor or an integrated development environment (IDE) such as Visual Studio Code or IntelliJ IDEA. Additionally, Ubuntu's terminal can be used to run server applications and manage the server environment. Finally, one can utilize Ubuntu's robust networking capabilities to configure and manage server applications, such as setting up web servers, databases, and other server-related tasks.
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How can one simulate a kernel panic in Linux?
To simulate a kernel panic in Linux, you can use the Magic SysRq key. First, you need to enable the Magic SysRq key by setting the value of /proc/sys/kernel/sysrq to 1. Then, you can trigger a kernel panic by pressing Alt + SysRq + C. This will cause the system to crash and display a kernel panic message. It is important to note that triggering a kernel panic should only be done for testing purposes and can result in data loss.
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How can I stop pinging in the Linux kernel?
To stop pinging in the Linux kernel, you can disable the ICMP echo requests by modifying the kernel parameters. You can do this by setting the value of `icmp_echo_ignore_all` to 1 in the `/proc/sys/net/ipv4/` directory. This will prevent the kernel from responding to ping requests. Additionally, you can also use firewall rules to block incoming ICMP echo requests.
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